Tuesday, 20 September 2011

Hyperdense thalami : Krabbe disease

2yo male with delayed milestone. Birth history unremarkable.


CT brain salient features:

  • Hyperdense thalami.
  • Cortical atrophy marked in frontal regions.

Possible DDs: Krabbes disease > GM Gangliosidosis.

Profund perinatal ischemia unlikely as there is no supporting history and periventricular leukomalacia. 

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